Freund Y, Chauvin A, Bloom B. (2022-03-08). Diagnostic Strategy Using an Elevated Age-Adjusted D-Dimer Threshold and Thromboembolic Events in the Emergency Department—Reply. jamanetwork.com In Reply We agree that the definition of the failure rate is controversial and that the denominator should be the number of patients in whom the strategy was effectively applied. In our study, this represented 80% of the population (patients with a YEARS score of 0).